A new asymptotic analysis of the Kimura model shows that the different predictions are not consequences of the number of alleles assumed but rather are attributable to assumptions concerning the relative magnitudes of per locus mutation rates, the phenotypic effects of mutation, and the intensity of selection. The published analyses of these models lead to qualitatively different predictions concerning the dependence of the equilibrium genetic variance on the underlying biological parameters. Latter and Bulmer analyzed a model with diallelic loci. ![]() Lande and Fleming analyzed extensions of a model originally treated by Kimura which assumes a continuum of possible allelic effects at each locus. Each is reviewed and a new analysis and model are presented. Several analyses have appeared of two distinct models with n additive polygenic loci subject to mutation and stabilizing selection. ![]() Lande proposed that high levels of heritable variation may be maintained by mutation in the face of stabilizing selection. Most quantitative traits in most populations exhibit heritable genetic variation.
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